About the cover

November 2011 Volume 7 No 11

An in silico high-throughput screen of the dopamine D3 receptor based on a homology model prior to publication of the crystal structure and a subsequent virtual screen based on the crystal structure of the receptor after it became available both identified new ligands with verified activities. The image is a rendition of the homology model of the G protein–coupled receptor, plus seven new ligands from the homology model screen. Cover art by Erin Dewalt, based on an image from Ryan Coleman. Article, p769