Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lipids

COX-2's new role in inflammation

COX-2 is the enzyme largely responsible for causing inflammation, a common mechanism of disease. A study now reports that derivatives generated by COX-2 from naturally occurring ω-3 fatty acids are anti-inflammatory mediators.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: COX-2-generated pro- and anti-inflammatory lipid mediators from ω-3 and ω-6 fatty acids.

References

  1. Groeger, A.G. et al. Nat. Chem. Biol. 6, 433–441 (2010).

    Article  CAS  Google Scholar 

  2. Gilroy, D.W., Colville-Nash, P.R., Chivers, W.J., Paul-Clark, M.J. & Willoughby, D.A. Nat. Med. 5, 698–701 (1999).

    Article  CAS  Google Scholar 

  3. Serhan, C.N., Yacoubian, S. & Yang, R. Annu. Rev. Pathol. Mech. Dis. 3, 279–312 (2008).

    Article  CAS  Google Scholar 

  4. Serhan, C.N. & Chiang, N. Br. J. Pharmacol. 153, S200–S215 (2008).

    Article  CAS  Google Scholar 

  5. Musiek, E.S. et al. J. Biol. Chem. 283, 19927–19935 (2008).

    Article  CAS  Google Scholar 

  6. Schwab, J.M., Chiang, N., Arita, M. & Serhan, C.N. Nature 447, 869–874 (2007).

    Article  CAS  Google Scholar 

  7. Marcheselli, V.L. et al. J. Biol. Chem. 278, 43807–43817 (2003).

    Article  CAS  Google Scholar 

  8. Bazan, N.G. J. Lipid Res. 50, S400–S405 (2009).

    Article  Google Scholar 

  9. Serhan, C.N. et al. J. Exp. Med. 196, 1025–1037 (2002).

    Article  CAS  Google Scholar 

  10. Krishnamoorthy, S. et al. Proc. Natl. Acad. Sci. USA 107, 1660–1665 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chu Chen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, C. COX-2's new role in inflammation. Nat Chem Biol 6, 401–402 (2010). https://doi.org/10.1038/nchembio.375

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.375

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing