Organic synthesis plays a leading role in the discovery of small molecules for the exploration of biological systems. Therefore, the development of efficient strategies for the preparation of these molecules is a necessary aspect of the small-molecule approach to chemical biology.
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Change history
18 March 2010
In the version of this article initially published, the palladium catalyst was incorrectly drawn as PdPh4. The molecular formula is actually Pd(PPh3)4. The error has been corrected in the HTML and PDF versions of the article.
References
Schreiber, S.L. Chemical Biology: From Small Molecules to Systems Biology and Drug Design (Wiley-VCH, 2008).
Leibeling, M. et al. Nat. Chem. Biol. 6, 199–201 (2010).
Stanton, B.Z. et al. Nat. Chem. Biol. 5, 154–156 (2009).
Bender C.F. et al. J. Am. Chem. Soc. 131, 11351–11352 (2009)
Wong, C.-H. Carbohydrate-based Drug Discovery (Wiley-VCH, 2003).
Hegedus, L. Transition Metals in the Synthesis of Complex Organic Molecules (University Science Books, 1999).
Poli, G. et al. Tetrahedron 56, 5959–5989 (2000).
Payne, D.J. et al. Nat. Rev. Drug Disc. 6, 29–40 (2007).
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Young, D. An upfront investment. Nat Chem Biol 6, 174–175 (2010). https://doi.org/10.1038/nchembio.325
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DOI: https://doi.org/10.1038/nchembio.325
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