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Synthetic chemistry

An upfront investment

A Corrigendum to this article was published on 01 April 2010

This article has been updated

Organic synthesis plays a leading role in the discovery of small molecules for the exploration of biological systems. Therefore, the development of efficient strategies for the preparation of these molecules is a necessary aspect of the small-molecule approach to chemical biology.

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Figure 1: Synthesis of chroman and isochroman scaffolds.

Change history

  • 18 March 2010

    In the version of this article initially published, the palladium catalyst was incorrectly drawn as PdPh4. The molecular formula is actually Pd(PPh3)4. The error has been corrected in the HTML and PDF versions of the article.

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Correspondence to Damian W Young.

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Young, D. An upfront investment. Nat Chem Biol 6, 174–175 (2010). https://doi.org/10.1038/nchembio.325

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