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Molecular probes

Getting lucky in the lysosome

Nature Chemical Biology volume 6, pages 881–883 (2010)Cite this article

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Conjugation of a known, mechanism-based glycosidase inhibitor to sensitive fluorophores yielded unexpectedly potent and selective probes for quantifying active lysosomal glucocerebrosidase. These conjugates could prove to be invaluable tools for diagnosing and studying Gaucher disease.

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Figure 1: Getting a grip on GBA.

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Authors and Affiliations

  1. Tom Wennekes and Stephen G. Withers are in the Department of Chemistry and Center for High-Throughput Biology, Ethan D. Goddard-Borger, University of British Columbia, Vancouver, British Columbia, Canada.,

    Ethan D Goddard-Borger, Tom Wennekes & Stephen G Withers

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  1. Ethan D Goddard-Borger
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  2. Tom Wennekes
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  3. Stephen G Withers
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Correspondence to Stephen G Withers.

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The authors declare no competing financial interests.

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Goddard-Borger, E., Wennekes, T. & Withers, S. Getting lucky in the lysosome. Nat Chem Biol 6, 881–883 (2010). https://doi.org/10.1038/nchembio.470

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