A new method to monitor interactions between cell surface proteins reveals that interaction of the neuronal cell surface adhesion proteins neurexin and neuroligin is increased at synapses during a stimulus or developmental activity. This increased activity-dependent surface density of neurexin–neuroligin complexes is subsequently required for maturation of synapses.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chen, I. & Ting, A.Y. Curr. Opin. Biotechnol. 16, 35–40 (2005).
Chen, I., Howarth, M., Lin, W. & Ting, A.Y. Nat. Methods 2, 99–104 (2005).
Thyagarajan, A. & Ting, A.Y. Cell 143, 1–14 (2010).
Feinberg, E.H. et al. Neuron 57, 353–363 (2008).
Howarth, M. et al. Nat. Methods 3, 267–273 (2006).
Fernández-Suárez, M., Chen, T.S. & Ting, A.Y. J. Am. Chem. Soc. 130, 9251–9253 (2008).
Südhof, T.C. Nature 455, 903–911 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Miyawaki, A. Visualizing a neuronal handshake. Nat Chem Biol 6, 885–886 (2010). https://doi.org/10.1038/nchembio.486
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.486