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Brief Communication

Nature Chemical Biology 5, 462–464 (1 July 2009) | doi:10.1038/nchembio.177

Chromatin-level regulation of biosynthetic gene clusters

Jin Woo Bok , Yi-Ming Chiang , Edyta Szewczyk , Yazmid Reyes-Dominguez , Ashley D Davidson , James F Sanchez , Hsien-Chun Lo , Kenji Watanabe , Joseph Strauss , Berl R Oakley , Clay C C Wang & Nancy P Keller

Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans.