Commentary abstract
Nature Chemical Biology 5, 441 - 447 (2009)
Published online: 17 June 2009 | Corrected online: 17 June 2009 | doi:10.1038/nchembio0709-441
There is an Erratum (August 2009) associated with this Commentary.
A crowdsourcing evaluation of the NIH chemical probes
Tudor I Oprea1, Cristian G Bologa2, Scott Boyer3, Ramona F Curpan4, Robert C Glen5, Andrew L Hopkins6, Christopher A Lipinski7, Garland R Marshall8, Yvonne C Martin9, Liliana Ostopovici-Halip10, Gilbert Rishton11, Oleg Ursu12, Roy J Vaz13, Chris Waller14, Herbert Waldmann15 & Larry A Sklar16
- Tudor I. Oprea is at the University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
- Cristian G. Bologa is at the University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
- Scott Boyer is in Global Safety Assessment, AstraZeneca R&D, Mölndal, Sweden.
- Ramona F. Curpan is at the University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA, and the Institute of Chemistry, Romanian Academy, Timisoara, Romania.
- Robert C. Glen is at the Unilever Centre for Molecular Science Informatics, Department of Chemistry, Cambridge, UK.
- Andrew L. Hopkins is in the Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Dundee, UK.
- Christopher A. Lipinski is at Melior Discovery, Waterford, Connecticut, USA.
- Garland R. Marshall is at the Center for Computational Biology, Washington University, St. Louis, Missouri, USA.
- Yvonne C. Martin is a consultant based in Waukegan, Illinois, USA.
- Liliana Ostopovici-Halip is at the University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA, and the Institute of Chemistry, Romanian Academy, Timisoara, Romania.
- Gilbert Rishton is at the Channel Islands Alzheimer's Institute, California State University, Channel Islands, Camarillo, California, USA.
- Oleg Ursu is at the University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
- Roy J. Vaz is at Sanofi-Aventis Pharmaceuticals, Bridgewater, New Jersey, USA.
- Chris Waller is in Chemistry Informatics, Pfizer Global R&D, Pfizer, Groton, Connecticut, USA.
- Herbert Waldmann is at the Max-Planck Institut für Molekulare Physiologie, Abteilung IV-Chemische Biologie, Dortmund, Germany, and Technische Universität Dortmund, Faculty of Chemistry, Chemical Biology, Dortmund, Germany.
- Larry A. Sklar is at the University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Correspondence to: Tudor I Oprea1 e-mail: toprea@salud.unm.edu
Correspondence to: Larry A Sklar16 e-mail: lskar@salud.unm.edu
Abstract
Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.
* In the version of this article initially published, the phrase "Though MLI and its pilot phase budget and superficially modest productivity were subject to industrial criticism" originally cited reference 3, but should cite reference 2. The error has been corrected in the HTML and PDF versions of the article.
