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Brief Communication
Nature Chemical Biology 5, 394–396 (1 June 2009) | doi:10.1038/nchembio.162
A new screening assay for allosteric inhibitors of cSrc
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Abstract
Targeting kinases outside the highly conserved ATP pocket is thought to be a promising strategy for overcoming bottlenecks in kinase inhibitor research, such as limited selectivity and drug resistance. Here we report the development and application of a direct binding assay to detect small molecules that stabilize the inactive conformation of the tyrosine kinase cSrc.
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