News and Views


Nature Chemical Biology 5, 377 - 378 (2009)
Corrected online: 13 November 2009 | doi:10.1038/nchembio0609-377



There is an Erratum (December 2009) associated with this News and Views.

S1P1 signaling just keeps going and going and going...

Stuart Cahalan1 & Hugh Rosen1

  1. Stuart Cahalan and Hugh Rosen are in the Departments of Chemical Physiology and Immunology, The Scripps Research Institute,, La Jolla California, USA.
    e-mail: hrosen@scripps.edu


Synthetic agonists of sphingosine-1-phosphate receptor subtype 1 are able to generate long-term signaling that persists for hours after ligand-induced receptor internalization. These signals are independent of agonist potency, can be reversed after receptor internalization by specific antagonists, and show a distinct acyl-chain-length structure-activity relationship.

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* In the version of this article initially published, the chemical structures for AFD-R, FTY720-P and OC5 were incorrect. The error has been corrected in the HTML and PDF versions of the article.

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