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Nature Chemical Biology 5, 278 - 279 (2009)
doi:10.1038/nchembio0509-278
Possible new RNA intermediate in RNA silencing
Samer Elkashef1 & Shou-Wei Ding1
- Samer Elkashef and Shou-Wei Ding are at the Center for Plant Cell Biology, Department of Plant Pathology and Microbiology, and Graduate Program for Genetics, Genomics and Bioinformatics, University of California, Riverside, California, USA. e-mail: shou-wei.ding@ucr.edu
Abstract
SGS3 is essential for antiviral silencing and the biogenesis of several classes of siRNAs in plants, but until now no biochemical function has been ascribed to it. Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5' overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.
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