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Nature Chemical Biology 5, 276 - 277 (2009)
doi:10.1038/nchembio0509-276

Revolutionary functional genomics liberates CHE

Fiona C Robertson1 & Alex A R Webb1

  1. Fiona C. Robertson and Alex A.R. Webb are at the Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, UK. e-mail: Alex.Webb@plantsci.cam.ac.uk


A high-throughput one-hybrid screen identifies a regulator of the Arabidopsis thaliana circadian gene CIRCADIAN CLOCK ASSOCIATED1 (CCA1). CCA1 HIKING EXPEDITION (CHE) represses CCA1 and physically interacts with TIMING OF CAB1 (TOC1) to link TOC1 with CCA1 in the clock.

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