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Nature Chemical Biology 5, 275 - 276 (2009)
doi:10.1038/nchembio0509-275
Traceless native protein labeling in mice
- Qing Lin and Reyna K.V. Lim are in the Department of Chemistry, State University of New York at Buffalo, Buffalo, New York, USA. e-mail: qinglin@buffalo.edu
Abstract
Labeling endogenous proteins in their natural environment with synthetic probes represents a major challenge in chemical biology. In a recent study, an elegant traceless labeling technique has been reported that allows attachment of biophysical probes to the targeted proteins in vivo.
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