In this issue - pv
doi:10.1038/nchembio0409-v
Table of contents
April 2009, Volume 5 No 4 pp193-266
About the coverTop of page
Editorial
This time - p193
doi:10.1038/nchembio0409-193
With a new administration and pending increases in scientific funding, chemical biologists in the United States have an unprecedented opportunity to influence the national scientific agenda.
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Elements
From students to scientists at XLAB - p194
Catherine Goodman
doi:10.1038/nchembio0409-194
Scientific principles and practices come together in a unique program for future scientists.
Full Text - From students to scientists at XLAB | PDF (351 KB) - From students to scientists at XLAB
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News and Views
Chemicals turn human embryonic stem cells towards beta cells - pp195 - 196
Yu-Ping Yang & Chris Wright
doi:10.1038/nchembio0409-195
Small-molecule library screening identifies simple imitators of the cellular signaling events that normally guide formation of the pancreas and its insulin-secreting beta cells, further enabling detailed analysis in vitro, or eventual diabetes therapies via large-scale differentiation of human stem cells.
Full Text - Chemicals turn human embryonic stem cells towards beta cells | PDF (2,613 KB) - Chemicals turn human embryonic stem cells towards beta cells
See also: Article by Chen et al.
Getting a handle on protein prenylation - pp197 - 198
James L Hougland & Carol A Fierke
doi:10.1038/nchembio0409-197
Protein prenylation plays a key role in the localization and function of many proteins, but the number and identities of prenylated proteins are unknown. A new study uses a multidisciplinary approach to provide a broad yet detailed snapshot of prenylation within the mammalian proteome.
Full Text - Getting a handle on protein prenylation | PDF (295 KB) - Getting a handle on protein prenylation
See also: Article by Nguyen et al.
Glycome 'fingerprints' provide definitive clues to HIV origins - pp198 - 199
Jun Hirabayashi
doi:10.1038/nchembio0409-198
It is well known that HIV-1 deceives the host immune system and usurps host cell machinery to replicate, but it is not known how this viral particle is released from the cell. A recent glycan profiling technique revealed that the glycome signatures of HIV-1 and host cell microvesicles are almost identical, providing important support for the 'exosome' hypothesis of viral release.
Full Text - Glycome 'fingerprints' provide definitive clues to HIV origins | PDF (243 KB) - Glycome 'fingerprints' provide definitive clues to HIV origins
See also: Article by Krishnamoorthy et al.
Back to the future of nucleic acid self-amplification - pp200 - 201
Andrew D Ellington
doi:10.1038/nchembio0409-200
The development of an autocatalytic, exponential replicator that is based solely on nucleic acids has implications for our understanding of the origins of life and potential applications in nucleic acid engineering.
Full Text - Back to the future of nucleic acid self-amplification | PDF (119 KB) - Back to the future of nucleic acid self-amplification
Hypoxia sensing goes gauche - pp202 - 203
Danica Galoni
Fujimori
doi:10.1038/nchembio0409-202
By converting prolyl to 4-hydroxyprolyl residues, prolyl hydroxylases induce a conformational bias into proteins. This conformational preference is a result of a stereoelectronic gauche effect and is crucial for protein-protein recognition in oxygen sensing.
Full Text - Hypoxia sensing goes gauche | PDF (128 KB) - Hypoxia sensing goes gauche
Research highlights - pp204 - 205
doi:10.1038/nchembio0409-204
Full Text - Research highlights | PDF (550 KB) - Research highlights
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Review
Emerging methods for the production of homogeneous human glycoproteins - pp206 - 215
Jamie R Rich & Stephen G Withers
doi:10.1038/nchembio.148
Abstract - Emerging methods for the production of homogeneous human glycoproteins | Full Text - Emerging methods for the production of homogeneous human glycoproteins | PDF (1,255 KB) - Emerging methods for the production of homogeneous human glycoproteins
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Brief Communication
Inhibition of Wnt signaling by Dishevelled PDZ peptides - pp217 - 219
Yingnan Zhang, Brent A Appleton, Christian Wiesmann, Ted Lau, Mike Costa, Rami N Hannoush & Sachdev S Sidhu
doi:10.1038/nchembio.152
Abstract - Inhibition of Wnt signaling by Dishevelled PDZ peptides | Full Text - Inhibition of Wnt signaling by Dishevelled PDZ peptides | PDF (293 KB) - Inhibition of Wnt signaling by Dishevelled PDZ peptides | Supplementary information | Chemical compounds
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Articles
Identification of a chemical probe for NAADP by virtual screening - pp220 - 226
Edmund Naylor, Abdelilah Arredouani, Sridhar R Vasudevan, Alexander M Lewis, Raman Parkesh, Akiko Mizote, Daniel Rosen, Justyn M Thomas, Minoru Izumi, A Ganesan, Antony Galione & Grant C Churchill
doi:10.1038/nchembio.150
Abstract - Identification of a chemical probe for NAADP by virtual screening | Full Text - Identification of a chemical probe for NAADP by virtual screening | PDF (728 KB) - Identification of a chemical probe for NAADP by virtual screening | Supplementary information | Chemical compounds
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging - pp227 - 235
Uyen T T Nguyen, Zhong Guo, Christine Delon, Yaowen Wu, Celine Deraeve, Benjamin Fränzel, Robin S Bon, Wulf Blankenfeldt, Roger S Goody, Herbert Waldmann, Dirk Wolters & Kirill Alexandrov
doi:10.1038/nchembio.149
Abstract - Analysis of the eukaryotic prenylome by isoprenoid affinity tagging | Full Text - Analysis of the eukaryotic prenylome by isoprenoid affinity tagging | PDF (571 KB) - Analysis of the eukaryotic prenylome by isoprenoid affinity tagging | Supplementary information | Chemical compounds
See also: News and Views by Hougland & Fierke
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation - pp236 - 243
Jing-Ruey J Yeh, Kathleen M Munson, Kamaleldin E Elagib, Adam N Goldfarb, David A Sweetser & Randall T Peterson
doi:10.1038/nchembio.147
Abstract - Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation | Full Text - Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation | PDF (1,305 KB) - Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation | Supplementary information | Chemical compounds
HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin - pp244 - 250
Lakshmi Krishnamoorthy, Julian W Bess Jr, Alex B Preston, Kunio Nagashima & Lara K Mahal
doi:10.1038/nchembio.151
Abstract - HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin | Full Text - HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin | PDF (541 KB) - HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin | Supplementary information | Chemical compounds
See also: News and Views by Hirabayashi
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing - pp251 - 257
Jemy A Gutierrez, Tamara Crowder, Agnes Rinaldo-Matthis, Meng-Chiao Ho, Steven C Almo & Vern L Schramm
doi:10.1038/nchembio.153
Abstract - Transition state analogs of 5[prime]-methylthioadenosine nucleosidase disrupt quorum sensing | Full Text - Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing | PDF (462 KB) - Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing | Supplementary information | Chemical compounds
A small molecule that directs differentiation of human ESCs into the pancreatic lineage - pp258 - 265
Shuibing Chen, Malgorzata Borowiak, Julia L Fox, René Maehr, Kenji Osafune, Lance Davidow, Kelvin Lam, Lee F Peng, Stuart L Schreiber, Lee L Rubin & Douglas Melton
doi:10.1038/nchembio.154
Abstract - A small molecule that directs differentiation of human ESCs into the pancreatic lineage | Full Text - A small molecule that directs differentiation of human ESCs into the pancreatic lineage | PDF (762 KB) - A small molecule that directs differentiation of human ESCs into the pancreatic lineage | Supplementary information | Chemical compounds
See also: News and Views by Yang & Wright
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Top of pageErratum
Erratum: A new family of ATP-dependent oligomerization-macrocyclization biocatalysts - p266
Nadia Kadi, Daniel Oves-Costales, Francisco Barona-Gomez & Gregory L Challis
doi:10.1038/nchembio0409-266
Full Text - Erratum: A new family of ATP-dependent oligomerization-macrocyclization biocatalysts | PDF (38 KB) - Erratum: A new family of ATP-dependent oligomerization-macrocyclization biocatalysts
