1. Danica Galoni Fujimori is in the Departments of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry, University of California, San Francisco, California, USA. e-mail: fujimori@cmp.ucsf.edu

Abstract

By converting prolyl to 4-hydroxyprolyl residues, prolyl hydroxylases induce a conformational bias into proteins. This conformational preference is a result of a stereoelectronic gauche effect and is crucial for protein-protein recognition in oxygen sensing.

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