1. Jun Hirabayashi is in the Research Center for Medical Glycomics, National Institute of Advanced Industrial Science and Technology, Umezono, Tsukuba, Ibaraki, Japan.
   e-mail: jun-hirabayashi@aist.go.jp

Abstract

It is well known that HIV-1 deceives the host immune system and usurps host cell machinery to replicate, but it is not known how this viral particle is released from the cell. A recent glycan profiling technique revealed that the glycome signatures of HIV-1 and host cell microvesicles are almost identical, providing important support for the 'exosome' hypothesis of viral release.

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