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Nature Chemical Biology 5, 148–149 (1 March 2009) | doi:10.1038/nchembio0309-148
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Abstract
Reactivity derails PKS prediction Polyketide synthases (PKSs) are multidomain proteins in which eachdomain performs a specific type of chemistry on the way to a polyketide product. Because the domains are highly conserved, it is often possible to predict not only the reaction performed by each domain but also the preferred substrate.
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