News and Views
Nature Chemical Biology 5, 146 - 147 (2009)
doi:10.1038/nchembio0309-146
Signal sequences get active
Irmgard Sinning1, Klemens Wild1 & Gert Bange1
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Irmgard Sinning, Klemens Wild and Gert Bange are in the Heidelberg University Biochemistry Center (BZH), University of Heidelberg, INF328, D-69120 Heidelberg, Germany.
e-mail: irmi.sinning@bzh.uni-heidelberg.de
Abstract
Newly synthesized secretory and membrane proteins contain cleavable signal sequences at the N terminus that allow for cotranslational protein targeting by interaction with the signal recognition particle (SRP). New results now suggest that signal sequences enable the conserved SRP RNA to accelerate complex formation with the SRP receptor.
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