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Nature Chemical Biology 5, 141 - 142 (2009)
doi:10.1038/nchembio0309-141
Intracellular zinc irritates TRPA1
Tue G Banke1 & Alan D Wickenden1
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Tue G. Banke and Alan D. Wickenden are at Johnson & Johnson Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, USA.
e-mail: awickend@its.jnj.com
Abstract
Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.
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RESEARCH
Zinc activates damage-sensing TRPA1 ion channelsNature Chemical Biology Article (01 Mar 2009)
