In this issue - pv
doi:10.1038/nchembio.231
Table of contents
October 2009, Volume 5 No 10 pp697-772
About the coverTop of page
Editorial
Assigning responsibility and credit - p697
doi:10.1038/nchembio.f.13
New policies refine the responsibilities of authors and require author contribution statements in Nature Chemical Biology research papers.
Full Text - Assigning responsibility and credit | PDF (99 KB) - Assigning responsibility and credit
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Commentary
Not all quiet on the noise front - pp699 - 704
Emma McCullagh, Justin Farlow, Christopher Fuller, Juliet Girard, Joanna Lipinski-Kruszka, Dan Lu, Thomas Noriega, Geoffrey Rollins, Russell Spitzer, Michael Todhunter & Hana El-Samad
doi:10.1038/nchembio.222
Abstract - Not all quiet on the noise front | Full Text - Not all quiet on the noise front | PDF (14,556 KB) - Not all quiet on the noise front
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Book Review
Cells' senses and sensibilities - pp705 - 706
Shay Tal & Johan Paulsson review Wetware by Dennis Bray
doi:10.1038/nchembio.229
Full Text - Cells' senses and sensibilities | PDF (101 KB) - Cells' senses and sensibilities
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News and Views
When two keys fit one lock, surprises follow - pp707 - 708
Michael Rosenblatt
doi:10.1038/nchembio.225
Parathyroid hormone (PTH) and PTH-related protein activate the same receptor but can produce divergent effects. Reports now describe two active conformations for the PTH receptor, one of which moves intracellularly—complexed with hormone and G protein—to produce a continued cAMP signal.
Full Text - When two keys fit one lock, surprises follow | PDF (668 KB) - When two keys fit one lock, surprises follow
See also: Article by Ferrandon et al.
Chemo-metabolic regulation of immune responses by Tregs - pp709 - 710
Anna Rubartelli & Roberto Sitia
doi:10.1038/nchembio.226
Chemo-metabolic processes such as redox remodeling and amino acid availability act as immunity rheostats, revealing a new mechanism regulating intercellular cross-talk between dendritic cells, regulatory T lymphocytes and effector T lymphocytes.
Full Text - Chemo-metabolic regulation of immune responses by Tregs | PDF (405 KB) - Chemo-metabolic regulation of immune responses by Tregs
See also: Brief Communication by Yan et al.
DNA-catalyzed hydrolysis of DNA phosphodiesters - pp710 - 711
Mostafa I Fekry & Kent S Gates
doi:10.1038/nchembio.224
Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn2+ and Mn2+ ions to accelerate this reaction by a factor of one hundred million (or more) have been identified and characterized.
Full Text - DNA-catalyzed hydrolysis of DNA phosphodiesters | PDF (132 KB) - DNA-catalyzed hydrolysis of DNA phosphodiesters
See also: Brief Communication by Chandra et al.
Research highlights - pp712 - 713
doi:10.1038/nchembio.230
Full Text - Research highlights | PDF (158 KB) - Research highlights
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Brief Communications
Cell-selective metabolic labeling of proteins - pp715 - 717
John T Ngo, Julie A Champion, Alborz Mahdavi, I Caglar Tanrikulu, Kimberly E Beatty, Rebecca E Connor, Tae Hyeon Yoo, Daniela C Dieterich, Erin M Schuman & David A Tirrell
doi:10.1038/nchembio.200
Abstract - Cell-selective metabolic labeling of proteins | Full Text - Cell-selective metabolic labeling of proteins | PDF (792 KB) - Cell-selective metabolic labeling of proteins | Supplementary information | Chemical compounds
DNA-catalyzed sequence-specific hydrolysis of DNA - pp718 - 720
Madhavaiah Chandra, Amit Sachdeva & Scott K Silverman
doi:10.1038/nchembio.201
Abstract - DNA-catalyzed sequence-specific hydrolysis of DNA | Full Text - DNA-catalyzed sequence-specific hydrolysis of DNA | PDF (336 KB) - DNA-catalyzed sequence-specific hydrolysis of DNA | Supplementary information
See also: News and Views by Fekry & Gates
Extracellular redox modulation by regulatory T cells - pp721 - 723
Zhonghua Yan, Sanjay K Garg, Jonathan Kipnis & Ruma Banerjee
doi:10.1038/nchembio.212
Abstract - Extracellular redox modulation by regulatory T cells | Full Text - Extracellular redox modulation by regulatory T cells | PDF (335 KB) - Extracellular redox modulation by regulatory T cells | Supplementary information | Chemical compounds
See also: News and Views by Rubartelli & Sitia
Augmented photoswitching modulates immune signaling - pp724 - 726
Yixin Zhang, Frank Erdmann & Gunter Fischer
doi:10.1038/nchembio.214
Abstract - Augmented photoswitching modulates immune signaling | Full Text - Augmented photoswitching modulates immune signaling | PDF (295 KB) - Augmented photoswitching modulates immune signaling | Supplementary information | Chemical compounds
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Articles
Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate - pp727 - 733
Martina Pavlova, Martin Klvana, Zbynek Prokop, Radka Chaloupkova, Pavel Banas, Michal Otyepka, Rebecca C Wade, Masataka Tsuda, Yuji Nagata & Jiri Damborsky
doi:10.1038/nchembio.205
Abstract - Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate | Full Text - Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate | PDF (561 KB) - Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate | Supplementary information | Chemical compounds
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis - pp734 - 742
Sébastien Ferrandon, Timothy N Feinstein, Marian Castro, Bin Wang, Richard Bouley, John T Potts, Thomas J Gardella & Jean-Pierre Vilardaga
doi:10.1038/nchembio.206
Abstract - Sustained cyclic AMP production by parathyroid hormone receptor endocytosis | Full Text - Sustained cyclic AMP production by parathyroid hormone receptor endocytosis | PDF (931 KB) - Sustained cyclic AMP production by parathyroid hormone receptor endocytosis | Supplementary information | Chemical compounds
See also: News and Views by Rosenblatt
A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry - pp743 - 748
Françoise Baleux, Latino Loureiro-Morais, Yael Hersant, Pascal Clayette, Fernando Arenzana-Seisdedos, David Bonnaffé & Hugues Lortat-Jacob
doi:10.1038/nchembio.207
Abstract - A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry | Full Text - A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry | PDF (533 KB) - A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry | Supplementary information | Chemical compounds
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents - pp749 - 757
Jonathan W Day, Nickki Ottaway, James T Patterson, Vasily Gelfanov, David Smiley, Jas Gidda, Hannes Findeisen, Dennis Bruemmer, Daniel J Drucker, Nilika Chaudhary, Jenna Holland, Jazzminn Hembree, William Abplanalp, Erin Grant, Jennifer Ruehl, Hilary Wilson, Henriette Kirchner, Sarah Haas Lockie, Susanna Hofmann, Stephen C Woods, Ruben Nogueiras, Paul T Pfluger, Diego Perez-Tilve, Richard DiMarchi & Matthias H Tschöp
doi:10.1038/nchembio.209
Abstract - A new glucagon and GLP-1 co-agonist eliminates obesity in rodents | Full Text - A new glucagon and GLP-1 co-agonist eliminates obesity in rodents | PDF (755 KB) - A new glucagon and GLP-1 co-agonist eliminates obesity in rodents | Supplementary information
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 - pp758 - 764
Valerie Hindie, Adriana Stroba, Hua Zhang, Laura A Lopez-Garcia, Leila Idrissova, Stefan Zeuzem, Daniel Hirschberg, Francis Schaeffer, Thomas J D Jørgensen, Matthias Engel, Pedro M Alzari & Ricardo M Biondi
doi:10.1038/nchembio.208
Abstract - Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 | Full Text - Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 | PDF (681 KB) - Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 | Supplementary information | Chemical compounds
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum - pp765 - 771
Jing Yuan, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin & Xin-zhuan Su
doi:10.1038/nchembio.215
Abstract - Genetic mapping of targets mediating differential chemical phenotypes in : Plasmodium falciparum | Full Text - Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum | PDF (632 KB) - Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum | Supplementary information | Chemical compounds
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Top of pageErratum
Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries - p772
Matthew A Clark, Raksha A Acharya, Christopher C Arico-Muendel, Svetlana L Belyanskaya, Dennis R Benjamin, Neil R Carlson, Paolo A Centrella, Cynthia H Chiu, Steffen P Creaser, John W Cuozzo, Christopher P Davie, Yun Ding, G Joseph Franklin, Kurt D Franzen, Malcolm L Gefter, Steven P Hale, Nils J V Hansen, David I Israel, Jinwei Jiang, Malcolm J Kavarana, Michael S Kelley, Christopher S Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patricia F Medeiros, Jeffrey A Messer, Paul Myers, Heather O'Keefe, Matthew C Oliff, Cecil E Rise, Alexander L Satz, Steven R Skinner, Jennifer L Svendsen, Lujia Tang, Kurt van Vloten, Richard W Wagner, Gang Yao, Baoguang Zhao & Barry A Morgan
doi:10.1038/nchembio1009-772
Full Text - Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries | PDF (43 KB) - Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries
