About the cover
January 2009 Volume 5 No 1
Proteasomal substrate selection. Prakash et al. (p 29) mixed and matched a ubiquitin tag and an unstructured region, two signals for proteasomal targeting, on the protein complex components barnase and barstar. Attaching ubiquitin to barstar and an unstructured region to barnase resulted in degradation of barnase through an in trans targeting mechanism (see also News and Views by Wandless on p 3). Barstar modified with four ubiquitin domains is shown targeting the unstructured region of barnase to the proteasome. Cover art by Erin Boyle based on images provided by Sumit Prakash and Tomonao Inobe.
