News and Views
Nature Chemical Biology 5, 9 - 11 (2009)
doi:10.1038/nchembio0109-9
A road map of cellular protein homeostasis
Xiaolu L Ang1 & J Wade Harper1
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Xiaolu L. Ang and J. Wade Harper are in the Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02120, USA.
e-mail: wade_harper@hms.harvard.edu
Abstract
A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment. This approach sets the stage for systems-level analyses of the dynamics of the mammalian proteome.
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