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Nature Chemical Biology 4, 448–449 (1 August 2008) | doi:10.1038/nchembio0808-448

Turning down tau phosphorylation

Peter M Fischer

Post-translational modifications of proteins have long been known to be instrumental in the regulation of many physiological processes. The protein residue–specific reciprocal interplay between two such modifications, phosphorylation and a specific form of glycosylation, O-linked β-N-acetylglucosaminylation (O-GlcNAc; 1 in Fig.