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Nature Chemical Biology 4, 451–452 (1 August 2008) | doi:10.1038/nchembio0808-451

Navigating the RNA folding landscape

Ruben L Gonzalez

Presented with myriad possible folding pathways, individual ribozyme molecules have the intrinsic capacity to select that route that culminates in a stably folded, fully active native state (Fig. 1a).