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Nature Chemical Biology 4, 454 - 455 (2008)
doi:10.1038/nchembio0808-454
The ABCs of trans(porter) inhibition
Rachelle Gaudet1
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Rachelle Gaudet is in the Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.
e-mail: gaudet@mcb.harvard.edu
Abstract
Transporter proteins mediate the import of nutrients and the export of toxins across biological membranes. A new crystal structure of a bacterial ABC transporter reveals an unexpected mechanism for transporter inhibition by its transported substrate.
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RESEARCH
Structure of an ABC transporter in complex with its binding proteinNature Letters to Editor (08 Mar 2007)
