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Nature Chemical Biology 4, 451 - 452 (2008)
doi:10.1038/nchembio0808-451
Navigating the RNA folding landscape
Ruben L Gonzalez, Jr1
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Ruben L. Gonzalez, Jr. is in the Department of Chemistry, Columbia University, 3000 Broadway, MC 3126, New York, New York 10027, USA.
e-mail: rlg2118@columbia.edu
Abstract
Analysis of individual RNA folding reactions reveals that, as in proteins, cooperative interactions selectively drive RNA toward its biologically active, native conformation. This new work establishes a platform for future investigations of the physical principles underlying the assembly of large RNA enzymes.
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