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Nature Chemical Biology 4, 448 - 449 (2008)
doi:10.1038/nchembio0808-448
Turning down tau phosphorylation
Peter M Fischer1
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Peter M. Fischer is in the School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham NG7 2RD, UK.
e-mail: peter.fischer@nottingham.ac.uk
Abstract
Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological inhibition of tau deglycosylation may be a new way to suppress abnormal tau phosphorylation, known to be involved in the formation of neurofibrillary tangles in the brain.
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