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Brief Communication
Nature Chemical Biology 4, 405–407 (1 July 2008) | doi:10.1038/nchembio.91
Disparate proteome reactivity profiles of carbon electrophiles
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Abstract
Insights into the proteome reactivity of electrophiles are crucial for designing activity-based probes for enzymes lacking cognate affinity labels. Here, we show that different classes of carbon electrophiles exhibit markedly distinct amino acid labeling profiles in proteomes, ranging from selective reactivity with cysteine to adducts with several amino acids.
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