In this issue - pv
doi:10.1038/nchembio0708-v
Table of contents
July 2008, Volume 4 No 7 pp381-431
About the coverTop of page
Editorial
Correcting the scientific record - p381
doi:10.1038/nchembio0708-381
The retraction of a Nature Chemical Biology paper is a step toward a full accounting of a case of scientific misconduct.
Full Text - Correcting the scientific record | PDF (125 KB) - Correcting the scientific record
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Meeting Report
Small molecules and chemical tools at the interface - pp382 - 386
Robert H Newman & Jin Zhang
doi:10.1038/nchembio0708-382
Abstract - Small molecules and chemical tools at the interface | Full Text - Small molecules and chemical tools at the interface | PDF (651 KB) - Small molecules and chemical tools at the interface
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News and Views
Proteomes take the electrophilic bait - pp387 - 388
Thomas Kodadek
doi:10.1038/nchembio0708-387
New electrophilic reagents for activity-based protein profiling (ABPP) can discriminate between nucleophilic amino acids, such as cysteine, that are in different protein microenvironments. These reagents extend the reach of ABPP beyond serine proteases and other proteins with hyperreactive nucleophiles.
Full Text - Proteomes take the electrophilic bait | PDF (192 KB) - Proteomes take the electrophilic bait
See also: Brief Communication by Weerapana et al.
Unraveling a molecular target of macrolides - pp388 - 389
Karl-Heinz Altmann & Erick M Carreira
doi:10.1038/nchembio0708-388
Leucascandrolide A and neopeltolide are structurally related natural products with potent growth inhibitory activity. The synthesis of a designed analog of leucascandrolide A and its evaluation in a yeast haploinsufficiency screen has revealed the cytochrome bc1 complex as a molecular target of these compounds.
Full Text - Unraveling a molecular target of macrolides | PDF (213 KB) - Unraveling a molecular target of macrolides
See also: Article by Ulanovskaya et al.
Peering inside the black box to find enzyme-bound intermediates - pp390 - 391
Craig Townsend
doi:10.1038/nchembio0708-390
The NMR structures of three intermediates bound to the pyridoxal-synthesizing enzyme Pdx1 illuminate its complex catalytic cycle. The success of this approach with a high-molecular-weight protein should encourage further applications of NMR techniques for characterizing enzyme reaction pathways.
Full Text - Peering inside the black box to find enzyme-bound intermediates | PDF (119 KB) - Peering inside the black box to find enzyme-bound intermediates
See also: Article by Hanes et al.
Fish 'n clicks - pp391 - 392
James K Chen
doi:10.1038/nchembio0708-391
The zebrafish has provided insights into the mechanisms of vertebrate development, in large part due to its amenability to optical imaging. While fluorescent proteins and other genetically encoded reporters are valuable imaging tools, synthetic probes can reveal dynamical processes such as glycan biosynthesis that are undetectable by conventional methods.
Modest membrane hydrogen bonds deliver rich results - pp393 - 394
Gevorg Grigoryan & William F DeGrado
doi:10.1038/nchembio0708-393
The significance of hydrogen bonds in protein structure was recognized as early as 1936 by Mirsky and Pauling, and the importance of hydrogen bonds in water-soluble proteins has since been studied extensively. Now a new paper takes an important step forward in characterizing the energetic significance of hydrogen bonds in membrane-soluble proteins.
Full Text - Modest membrane hydrogen bonds deliver rich results | PDF (172 KB) - Modest membrane hydrogen bonds deliver rich results
Research highlights - p395
doi:10.1038/nchembio0708-395
Full Text - Research highlights | PDF (179 KB) - Research highlights
Top of pageInsights into signaling from the
Perspective
Insights into signaling from the 
2-adrenergic receptor structure - pp397 - 403
Martin Audet & Michel Bouvier
doi:10.1038/nchembio.97
Abstract - Insights into signaling from the [beta]: 2: -adrenergic receptor structure | Full Text - Insights into signaling from the 
2-adrenergic receptor structure | PDF (1,097 KB) - Insights into signaling from the 2-adrenergic receptor structure
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Brief Communications
Disparate proteome reactivity profiles of carbon electrophiles - pp405 - 407
Eranthie Weerapana, Gabriel M Simon & Benjamin F Cravatt
doi:10.1038/nchembio.91
Abstract - Disparate proteome reactivity profiles of carbon electrophiles | Full Text - Disparate proteome reactivity profiles of carbon electrophiles | PDF (190 KB) - Disparate proteome reactivity profiles of carbon electrophiles | Supplementary information | Chemical compounds
See also: News and Views by Kodadek
Small-molecule activation of neuronal cell fate - pp408 - 410
Jay W Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie-Shan Tang, Ilya Bezprozvanny, Doug E Frantz & Jenny Hsieh
doi:10.1038/nchembio.95
Abstract - Small-molecule activation of neuronal cell fate | Full Text - Small-molecule activation of neuronal cell fate | PDF (285 KB) - Small-molecule activation of neuronal cell fate | Supplementary information | Chemical compounds
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Articles
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis - pp411 - 417
Emmelie Å Jansson, Liyue Huang, Ronny Malkey, Mirco Govoni, Carina Nihlén, Annika Olsson, Margareta Stensdotter, Joel Petersson, Lena Holm, Eddie Weitzberg & Jon O Lundberg
doi:10.1038/nchembio.92
Abstract - A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis | Full Text - A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis | PDF (250 KB) - A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis | Supplementary information | Chemical compounds
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide - pp418 - 424
Olesya A Ulanovskaya, Jelena Janjic, Masato Suzuki, Simran S Sabharwal, Paul T Schumacker, Stephen J Kron & Sergey A Kozmin
doi:10.1038/nchembio.94
Abstract - Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide | Full Text - Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide | PDF (399 KB) - Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide | Supplementary information | Chemical compounds
See also: News and Views by Altmann & Carreira
13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase - pp425 - 430
Jeremiah W Hanes, Ivan Keresztes & Tadhg P Begley
doi:10.1038/nchembio.93
Abstract - 13: C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase | Full Text - 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase | PDF (1,115 KB) - 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase | Supplementary information | Chemical compounds
See also: News and Views by Townsend
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Top of pageRetraction
Retraction: Small molecule–based reversible reprogramming of cellular lifespan - p431
Jaejoon Won, Mina Kim, Nuri Kim, Jin Hee Ahn, Woo Gil Lee, Sung Soo Kim, Ki-Young Chang, Yong-Weon Yi & Tae Kook Kim
doi:10.1038/nchembio0708-431
Full Text - Retraction: Small molecule–based reversible reprogramming of cellular lifespan | PDF (59 KB) - Retraction: Small molecule–based reversible reprogramming of cellular lifespan
