About the cover
July 2008 Volume 4 No 7
Proteome reactivity of carbon electrophiles. To expand the range of activity-based protein profiling, Weerapana et al. (p 405) tested the reactivities of five carbon electrophiles in proteomic samples. These electrophiles displayed a variety of reactivity and specificity profiles, which suggests that these compounds will provide versatile scaffolds for designing the next generation of activity-based probes (see also News and Views by Kodadek on p 387). The three most reactive electrophiles (in white) and selected target proteins (in color) are shown in a background of unreacted proteins (in gray). Cover art by Erin Boyle based on images provided by Gabriel Simon.
