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Nature Chemical Biology 4, 387 - 388 (2008)
doi:10.1038/nchembio0708-387
Proteomes take the electrophilic bait
Thomas Kodadek1
- Thomas Kodadek is in the Division of Translational Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA. e-mail: thomas.kodadek@utsouthwestern.edu
Abstract
New electrophilic reagents for activity-based protein profiling (ABPP) can discriminate between nucleophilic amino acids, such as cysteine, that are in different protein microenvironments. These reagents extend the reach of ABPP beyond serine proteases and other proteins with hyperreactive nucleophiles.
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