In this issue - pv
doi:10.1038/nchembio0608-v
Table of contents
June 2008, Volume 4 No 6 pp323-379
- In This Issue
- Editorial
- Obituary
- Commentary
- Book Review
- News and Views
- Brief Communications
- Articles
- Erratum
- Corrigendum
Top of page
Editorial
To the editor - p323
doi:10.1038/nchembio0608-323
Correspondence in scientific journals is an essential mechanism for mediating scientific debates, but emerging online technologies offer new ways to foster scientific communication.
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Obituary
Jeremy R Knowles 1935–2008 - p325
Dagmar Ringe & Gregory A Petsko
doi:10.1038/nchembio0608-325
Full Text - Jeremy R Knowles 1935–2008 | PDF (78 KB) - Jeremy R Knowles 1935–2008
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Commentary
Submitting antibodies to binding arbitration - pp326 - 329
Stephen W Michnick & Sachdev S Sidhu
doi:10.1038/nchembio0608-326
For the last 30 years, the production of affinity reagents and particularly antibodies for research and therapeutic applications has been dominated by hybridoma and polyclonal technologies, while more modern, reliable and inexpensive approaches have lagged. Here we discuss why this is the case and how a cultural shift in the biomedical research community could bring the new technologies for creating antibodies and other tailor-designed binding proteins into the mainstream, with the potential for myriad new applications in research and medicine.
Full Text - Submitting antibodies to binding arbitration | PDF (539 KB) - Submitting antibodies to binding arbitration
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Book Review
Creating chirality - p330
Yun-Ming Lin reviews Asymmetric Synthesis with Chemical and Biological Methods by Dieter Enders & Karl-Erich Jaeger
doi:10.1038/nchembio0608-330
Full Text - Creating chirality | PDF (96 KB) - Creating chirality
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News and Views
Stopping replication, at the beginning - pp331 - 332
Peter K Jackson
doi:10.1038/nchembio0608-331
A new pharmacological inhibitor of the Cdc7 protein kinase can block replication initiation without activating the replication checkpoint, thus validating replication initiation as a new target class for cancer cell chemotherapy.
Full Text - Stopping replication, at the beginning | PDF (245 KB) - Stopping replication, at the beginning
See also: Article by Montagnoli et al.
A gateway to study protein lysine methylation - pp332 - 334
Patrick Trojer & Danny Reinberg
doi:10.1038/nchembio0608-332
Lysine methyltransferases are well-known regulators of transcription through their methylation of histone lysine residues. Now high-throughput peptide arrays reveal non-histone substrates of G9a/KMT3C, which was previously known as a euchromatic histone H3K9-specific methyltransferase.
Full Text - A gateway to study protein lysine methylation | PDF (1,129 KB) - A gateway to study protein lysine methylation
See also: Brief Communication by Rathert et al.
Stopping malaria parasites dead in their tracks - pp334 - 335
Christian D Doerig
doi:10.1038/nchembio0608-334
The search for new antimalarial strategies takes a step forward with the discovery of a small parasitocidal molecule that inhibits a calcium-dependent protein kinase and may thereby interfere with parasite motility.
Full Text - Stopping malaria parasites dead in their tracks | PDF (835 KB) - Stopping malaria parasites dead in their tracks
See also: Article by Kato et al.
Chemical answers to epigenetic crosstalk - pp335 - 337
Nara Lee & Yi Zhang
doi:10.1038/nchembio0608-335
Crosstalk between histone modifications plays an important role in transcriptional regulation. In a recent study, an elegant chemical synthesis approach has been used to study the intricate relationship between two modifications associated with active transcription.
Full Text - Chemical answers to epigenetic crosstalk | PDF (597 KB) - Chemical answers to epigenetic crosstalk
A new path to auxin - pp337 - 339
Lucia C Strader & Bonnie Bartel
doi:10.1038/nchembio0608-337
Biosynthesis of essential hormones is often complex and redundant. Two independent genetic screens have converged to support a previously conjectured auxin biosynthetic pathway that is responsible for providing auxin during plant development and in response to environmental cues.
Full Text - A new path to auxin | PDF (362 KB) - A new path to auxin
Research highlights - p340
doi:10.1038/nchembio0608-340
Full Text - Research highlights | PDF (117 KB) - Research highlights
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Brief Communications
A global assembly line for cyanobactins - pp341 - 343
Mohamed S Donia, Jacques Ravel & Eric W Schmidt
doi:10.1038/nchembio.84
Abstract - A global assembly line for cyanobactins | Full Text - A global assembly line for cyanobactins | PDF (292 KB) - A global assembly line for cyanobactins | Supplementary information | Chemical compounds
Protein lysine methyltransferase G9a acts on non-histone targets - pp344 - 346
Philipp Rathert, Arunkumar Dhayalan, Marie Murakami, Xing Zhang, Raluca Tamas, Renata Jurkowska, Yasuhiko Komatsu, Yoichi Shinkai, Xiaodong Cheng & Albert Jeltsch
doi:10.1038/nchembio.88
Abstract - Protein lysine methyltransferase G9a acts on non-histone targets | Full Text - Protein lysine methyltransferase G9a acts on non-histone targets | PDF (173 KB) - Protein lysine methyltransferase G9a acts on non-histone targets | Supplementary information | Chemical compounds
See also: News and Views by Trojer & Reinberg
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Metal swap between Zn7-metallothionein-3 and amyloid-
Articles
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility - pp347 - 356
Nobutaka Kato, Tomoyo Sakata, Ghislain Breton, Karine G Le Roch, Advait Nagle, Carsten Andersen, Badry Bursulaya, Kerstin Henson, Jeffrey Johnson, Kota Arun Kumar, Felix Marr, Daniel Mason, Case McNamara, David Plouffe, Vandana Ramachandran, Muriel Spooner, Tove Tuntland, Yingyao Zhou, Eric C Peters, Arnab Chatterjee, Peter G Schultz, Gary E Ward, Nathanael Gray, Jeffrey Harper & Elizabeth A Winzeler
doi:10.1038/nchembio.87
Abstract - Gene expression signatures and small-molecule compounds link a protein kinase to : Plasmodium falciparum: motility | Full Text - Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility | PDF (611 KB) - Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility | Supplementary information | Chemical compounds
See also: News and Views by Doerig
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity - pp357 - 365
Alessia Montagnoli, Barbara Valsasina, Valter Croci, Maria Menichincheri, Sonia Rainoldi, Vanessa Marchesi, Marcello Tibolla, Pierluigi Tenca, Deborah Brotherton, Clara Albanese, Veronica Patton, Rachele Alzani, Antonella Ciavolella, Francesco Sola, Antonio Molinari, Daniele Volpi, Nilla Avanzi, Francesco Fiorentini, Marina Cattoni, Sandra Healy, Dario Ballinari, Enrico Pesenti, Antonella Isacchi, Jurgen Moll, Aaron Bensimon, Ermes Vanotti & Corrado Santocanale
doi:10.1038/nchembio.90
Abstract - A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity | Full Text - A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity | PDF (447 KB) - A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity | Supplementary information | Chemical compounds
See also: News and Views by Jackson
Metal swap between Zn7-metallothionein-3 and amyloid-
–Cu protects against amyloid- toxicity - pp366 - 372
Gabriele Meloni,
Vanessa Sonois,
Tamara Delaine,
Luc Guilloreau,
Audrey Gillet,
Justin Teissié,
Peter Faller
&
Milan Va
ák
doi:10.1038/nchembio.89
Abstract - Metal swap between Zn: 7: -metallothionein-3 and amyloid-[beta]-Cu protects against amyloid-[beta] toxicity | Full Text - Metal swap between Zn7-metallothionein-3 and amyloid-
–Cu protects against amyloid- toxicity | PDF (325 KB) - Metal swap between Zn7-metallothionein-3 and amyloid-–Cu protects against amyloid- toxicity | Supplementary information | Chemical compounds
Activation of the endocannabinoid system by organophosphorus nerve agents - pp373 - 378
Daniel K Nomura, Jacqueline L Blankman, Gabriel M Simon, Kazutoshi Fujioka, Roger S Issa, Anna M Ward, Benjamin F Cravatt & John E Casida
doi:10.1038/nchembio.86
Abstract - Activation of the endocannabinoid system by organophosphorus nerve agents | Full Text - Activation of the endocannabinoid system by organophosphorus nerve agents | PDF (270 KB) - Activation of the endocannabinoid system by organophosphorus nerve agents | Supplementary information | Chemical compounds
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Erratum
Erratum: Single-molecule analysis of human telomerase monomer - p379
David Alves, Haitao Li, Rosalind Codrington, Angel Orte, Xiaojun Ren, David Klenerman & Shankar Balasubramanian
doi:10.1038/nchembio0608-379a
Full Text - Erratum: Single-molecule analysis of human telomerase monomer | PDF (170 KB) - Erratum: Single-molecule analysis of human telomerase monomer
Top of pageCorrigendum: NF
Top of pageCorrigendum
Corrigendum: NF
B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses - p379
Kendall W Nettles, John B Bruning, German Gil, Jason Nowak, Sanjay K Sharma, Johnnie B Hahm, Kristen Kulp, Richard B Hochberg, Haibing Zhou, John A Katzenellenbogen, Benita S Katzenellenbogen, Younchang Kim, Andrzej Joachimiak & Geoffrey L Greene
doi:10.1038/nchembio0608-379b
Full Text - Corrigendum: NF
B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses | PDF (170 KB) - Corrigendum: NFB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
