Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
News and Views
Nature Chemical Biology 4, 331–332 (1 June 2008) | doi:10.1038/nchembio0608-331
Stopping replication, at the beginning
Abstract
With the current frenzy for molecularly targeted chemotherapy, it's hard to imagine that the earliest cancer therapies used nitrogen mustards and folic acid analogs. These agents achieved their efficacy by alkylative damage of DNA or by inhibiting the synthesis of nucleotide precursors.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
