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Stopping replication, at the beginning

Nature Chemical Biology volume 4, pages 331–332 (2008)Cite this article

A new pharmacological inhibitor of the Cdc7 protein kinase can block replication initiation without activating the replication checkpoint, thus validating replication initiation as a new target class for cancer cell chemotherapy.

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Figure 1: Cdc7 regulation of DNA replication and checkpoints in normal and tumor cells.

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Authors and Affiliations

  1. Department of Cell Regulation, Department of Pathology, Peter K. Jackson is at Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA and Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, California 94305, USA. pjackson@gene.com,

    Peter K Jackson

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  1. Peter K Jackson
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Jackson, P. Stopping replication, at the beginning. Nat Chem Biol 4, 331–332 (2008). https://doi.org/10.1038/nchembio0608-331

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  • DOI: https://doi.org/10.1038/nchembio0608-331

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