1. Nara Lee and Yi Zhang are in the Department of Biochemistry and Biophysics and the Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 100 West Drive, Chapel Hill, North Carolina 27599-7295, USA.
   e-mail: yi_zhang@med.unc.edu

Abstract

Crosstalk between histone modifications plays an important role in transcriptional regulation. In a recent study, an elegant chemical synthesis approach has been used to study the intricate relationship between two modifications associated with active transcription.

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