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Nature Chemical Biology 4, 277 (1 May 2008) | doi:10.1038/nchembio0508-277
Research highlights
Abstract
Sensing SAH selectively Biological methylation reactions typically involve the transfer of the methyl group from the sulfonium group of (S)-adenosyl-L-methionine (SAM) to a target molecule, resulting in the generation of (S)-adenosyl-L-homocysteine (SAH). SAH inhibits many SAM-dependent enzymes and thus can be toxic at high concentrations.
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