News and Views
Nature Chemical Biology 4, 273 - 275 (2008)
doi:10.1038/nchembio0508-273
Do-it-yourself enzymes
Vikas Nanda1
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Vikas Nanda is at the Center for Advanced Biotechnology and Medicine and the Department of Biochemistry at the Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 679 Hoes Lane West, Piscataway, New Jersey 08854, USA.
e-mail: nanda@cabm.rutgers.edu
Abstract
Enzymes have long captivated biologists and chemists by performing difficult reactions rapidly and selectively in aqueous environments. The designs of enzymes catalyzing a retro-aldol reaction and a Kemp elimination demonstrate that complex, biochemically novel reactions can be achieved using cutting-edge computational methods.
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