News and Views
Nature Chemical Biology 4, 270 - 271 (2008)
doi:10.1038/nchembio0508-270
Engineering protease specificity made simple, but not simpler
Enrico Di Cera1
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Enrico Di Cera is in the Department of Biochemistry and Molecular Biophysics, Washington University Medical School, Box 8231, St. Louis, Missouri 63110, USA.
e-mail: enrico@wustl.edu
Abstract
Engineering protease specificity has been a long sought research goal. New findings on OmpT, an outer membrane protease from Escherichia coli, reveal the remarkable success of a simple strategy.
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