About the cover
April 2008 Volume 4 No 4
A carbohydrate microarray provides insights into the antimalarial immune response. Kamena et al. (p 238) spotted synthetic GPI glycans onto glass slides to create a 'GPI chip'. Using this chip, the authors characterized the binding of anti-GPI antibodies from people in malaria-endemic and malaria-free regions and before and after malarial exposure (see also News and Views by Ferguson on p (223). Shown are images of the carbohydrate microarrays incubated with human sera, Giesma-stained red blood cells infected with Plasmodium falciparum and the chemical structures of GPI glycans displayed on the microarrays. Cover art by Erin Boyle based on images provided by Faustin Kamena and Marco Tamborrini.
