Brief Communication abstract
Nature Chemical Biology 4, 235 - 237 (2008)
Published online: 24 February 2008 | doi:10.1038/nchembio.74
Synthesis and absolute configuration of hormone 
1
Arata Yajima1,5, Yong Qin2,5, Xuan Zhou2, Naoki Kawanishi1, Xue Xiao2, Jue Wang2, Dan Zhang2, Yi Wu2, Tomoo Nukada1, Goro Yabuta1, Jianhua Qi3,4,5, Tomoyo Asano3 & Youji Sakagami3
An important biological event in phytopathogens of the genus Phytophthora is sexual reproduction, which is conducted by two mating types, A1 and A2. A factor known as hormone 
1 is secreted by the A1 mating type and induces the formation of sexual spores (oospores) in the A2 mating type. Here we describe the asymmetric synthesis and assignment of the absolute configuration of hormone 1 by oospore-inducing assays of the synthesized isomers.
- Department of Fermentation Science, Faculty of Applied Biological Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-ku, Tokyo 156-8502, Japan.
- Department of Chemistry of Medicinal Natural Products and Key Laboratory of Drug Targeting, West China School of Pharmacy, and State Key Laboratory of Biotherapy, Sichuan University, No. 17, Section 3, Renmin Nan Road, Chengdu 610041, China.
- Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
- School of Pharmacy, Fudan University, No. 138 Yi Xue Yuan Road, Shanghai 200032, China.
- These authors contributed equally to this work.
Correspondence to: Arata Yajima1,5 e-mail: ayaji@nodai.ac.jp
Correspondence to: Yong Qin2,5 e-mail: yongqin@scu.edu.cn
Correspondence to: Jianhua Qi3,4,5 e-mail: jhqi@fudan.edu.cn
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