Figure 1 - Known and proposed roles for human 2OG oxygenases with outline catalytic cycle.

See main text for identified roles of individual 2OG oxygenases; the requirement for O₂, 2OG, Fe(II) and the coproducts succinate and CO₂ are omitted for clarity. Color code: red, incorporated oxygen; blue, methyl residue acted upon. CPH, collagen proline (4R)-hydroxylase; P3H, proline (3S)-hydroxylase; LH, lysine hydroxylase; TMLH, trimethyllysine hydroxylase; GBBH, -butyrobetaine hydroxylase; PhyH/PAHX, phytanoyl-CoA hydroxylase; PHD1–PHD3, prolyl hydroxylase domain–containing proteins 1–3; FIH, factor inhibiting HIF; EGFH/AAH, epidermal growth factor hydroxylase; hABH2/3, AlkB homologs 2 and 3; FTO, fat mass and obesity associated; JMJD, jumonji domain–containing; R, methyl or hydrogen.