News and Views
Nature Chemical Biology 4, 161 - 162 (2008)
doi:10.1038/nchembio0308-161
Arresting malaria parasite egress from infected red blood cells
Marcus C S Lee1 & David A Fidock1
- Marcus C.S. Lee is in the Department of Microbiology and David A. Fidock is in the Department of Microbiology and the Department of Medicine, College of Physicians and Surgeons, Columbia University, Hammer HSC Room 1502, 701 West 168th Street, New York, New York 10032, USA. e-mail: df2260@columbia.edu
Abstract
The escape of mature malaria parasites from the confines of their host red blood cells is an essential yet poorly understood process. Recent studies now highlight a key role for parasite proteases that trigger the degradation of parasite and host membranes, leading to the egress of infectious parasite forms.
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