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Nature Chemical Biology 4, 159 - 160 (2008)
doi:10.1038/nchembio0308-159
Aggregator compounds confound amyloid fibrillization assay
Gilbert M Rishton1
- Gilbert M. Rishton is director of the Channel Islands Alzheimer's Institute, CSUCI, Aliso Hall, One University Drive, Camarillo, California 93012, USA. e-mail: gilbert.rishton@csuci.edu
Abstract
The highly sensitive and artificial biochemical assays that enable high-throughput screening are vulnerable to artifact-generating compounds that occur in drug screening collections. An investigation of known aggregator compounds and amyloid fibrillization inhibitors suggests that such inhibitors operate via a nonspecific mechanism in a well-used assay of amyloid fibrillization.
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