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Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase

Methylmalonyl coenzyme A mutase (MCM) catalyzes the adenosylcobalamin-dependent isomerization of methylmalonyl-CoA to succinyl-CoA. Adenosyltransferase, an enzyme that carries out the final step in biosynthesis of adenosylcobalamin, is shown to be involved in delivery of the cofactor to MCM.

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Figure 1: Coordination states of cobalamin and tailoring delivery of cobalamin from ATR to MCM.

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Bandarian, V. Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase. Nat Chem Biol 4, 158–159 (2008). https://doi.org/10.1038/nchembio0308-158

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