1. Christoph Loenarz and Christopher J. Schofield are in the Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, Mansfield Road, Oxford OX1 3TA, UK. e-mail: christopher.schofield@chem.ox.ac.uk

Abstract

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.

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