Review abstract

Nature Chemical Biology 4, 168 - 175 (2008)
Published online: 15 February 2008 | Corrected online: 26 June 2008 | doi:10.1038/nchembio.69



There is a Corrigendum (August 2008) associated with this Review.

There is a Corrigendum (August 2008) associated with this Review.

There is a Corrigendum (August 2008) associated with this Review.

There is a Corrigendum (August 2008) associated with this Review.

Synthetic fluorescent sensors for studying the cell biology of metals

Dylan W Domaille1, Emily L Que1 & Christopher J Chang1

Metals are essential for sustaining all forms of life, but alterations in their cellular homeostasis are connected to severe human disorders, including cancer, diabetes and neurodegenerative diseases. Fluorescent small molecules that respond to metal ions in the cell with appropriate selectivity and sensitivity offer the ability to probe physiological and pathological consequences of the cell biology of metals with spatial and temporal fidelity. Molecular imaging of normal and abnormal cellular metal ion pools using these new chemical tools provides a host of emerging opportunities for visualizing, in real time, aspects of metal accumulation, trafficking, and function or toxicity in living systems. This review presents a brief survey of available synthetic small-molecule sensor types for fluorescence detection of cellular metals.

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  1. 532A Latimer Hall, Department of Chemistry, University of California, Berkeley, California 94720, USA.

Correspondence to: Christopher J Chang1 e-mail: chrischang@berkeley.edu

* In the version of this article initially published, the chemical structures for S3 and RS2 in Figure 6 were incorrect. The error has been corrected in the HTML and PDF versions of the article.

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