News and Views
Nature Chemical Biology 4, 91 - 93 (2008)
doi:10.1038/nchembio0208-91
Losing inhibition with ketamine
Jeremy Seamans1
- Jeremy Seamans is in the Department of Psychiatry and the Brain Research Centre at the University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada. e-mail: seamans@interchange.ubc.ca
Abstract
Schizophrenia is thought to involve a dysfunction of glutamatergic and GABAergic signaling in the prefrontal cortex, but how these systems interact in the disease has been unclear. Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways.
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