News and Views
Nature Chemical Biology 4, 86 - 88 (2008)
Corrected online: 13 February 2009 | doi:10.1038/nchembio0208-86
There is a Corrigendum (March 2009) associated with this News and Views.
Small molecule versus DNA repair nanomachine
James T Stivers1
- James T. Stivers is in the Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical School, 725 North Wolfe Street, Baltimore, Maryland 21205, USA. e-mail: jstivers@jhmi.edu
Abstract
The MRN protein megacomplex mediates repair of double-stranded DNA breaks (DSBs) by tethering together broken ends of chromosomes and signaling a cascade of events required for DNA repair. The first small-molecule inhibitor that disrupts MRN function provides a valuable new tool for functional studies of DSB repair in cells.
* In the version of this article initially published, the chemical structure of mirin in Figure 1b was incorrect. The error has been corrected in the HTML and PDF versions of the article.
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