News and Views
Nature Chemical Biology 4, 722 - 723 (2008)
doi:10.1038/nchembio1208-722
Bcl-2 turns deadly
- Bing Qi and J. Marie Hardwick are in the W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205, USA. e-mail: mhardwic@jhsph.edu
Abstract
Small-molecule inhibitors of anti-apoptotic Bcl-2 proteins and BH3 mimetic peptides are promising anticancer agents. A recent study identifies a Nur77-based peptide that converts anti-apoptotic Bcl-2 proteins into pro-apoptotic molecules, providing another potential cancer therapeutic strategy.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Upgrading the BCL-2 NetworkNature Cell Biology News and Views (01 Dec 2006)
Ending the prolonged life of cancer cellsNature Chemical Biology News and Views (01 Jun 2005)
See all 3 matches for News And ViewsRESEARCH
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamiliesNature Cell Biology Article (01 Dec 2006)
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cellsLeukemia Original Article
See all 31 matches for Research
