1. Minoru Fukuda and Xingfeng Bao are in the Glycobiology Unit, Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. e-mail: minoru@burnham.org

Abstract

Cell-surface carbohydrates are synthesized in a step-wise fashion, yielding products with unique capping structures. A recent study has shown that carbohydrates at the cell surface can be further remodeled by an endogenous glycosidase to alter the carbohydrate structure, thus generating a new function.

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