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Nature Chemical Biology 4, 651–652 (1 November 2008) | doi:10.1038/nchembio1108-651

Proteolytic needles in the cellular haystack

Mari Enoksson & Guy S Salvesen

Like most post-translational protein modifications, proteolysis is of interest to the wide bioscience community primarily in the identity and consequence of its action on targets. Only when the protein target is known, and the modification site identified, can progress toward understanding the consequence of the modification evolve.